IFRs were modeled as a graph in which hydrophobic atoms were the nodes and the contacts between them were the edges. developed a method based on hydrophobic patch centroids to predict cross-inhibition, also known as inhibitor promiscuity, in serine proteases. In general, classical methods, such as sequence/structural alignments, are not appropriate for conservation detection when proteins have dissimilar sequences and/or structures. These strategies work well for rigid ligands as they result in structural alignments of good quality due to ligand-induced superimposition. Previous solutions for detecting structural binding motifs for a set of diverse proteins and a common ligand involved protein superimposition based on the ligand and subsequent clustering of the conserved residues or atoms interacting with this ligand. Here, we briefly review some recent works that are representative examples of the diverse techniques that have already been proposed. Several methods have been proposed to identify three-dimensional binding motifs. Thus, it is reasonable to expect that methods used to detect conserved interactions between proteins and ligands should be able to address both protein and ligand promiscuity. On the other hand, ligands can also be promiscuous, such as when one ligand is recognized by different proteins. On one hand, proteins can be promiscuous, as they interact with different ligands. We consider ligands to be small non-protein molecules. In this paper, we are interested in the interface between proteins and ligands. Therefore, IFR can be an invaluable source of information to support the identification of conserved interactions across a set of complexes. , protein structures are more conserved than their sequences, and IFRs are even more conserved than whole protein structures. Interface forming residues (IFR) are residues in the molecular interface region between proteins. Identifying conserved interactions between proteins and ligands that are reused across a protein family is a key factor for understanding molecular recognition processes and can contribute to rational drug design, target identification, lead discovery and ligand prediction. Understanding how protein-ligand interactions take place has been the goal of many research studies, as molecular recognition is pivotal in biological processes, including signal transduction, catalysis and the regulation of biological function, to name a few examples. A variety of protein functions can be attributed to or regulated by these interactions. At the molecular level, protein receptors constantly interact with small-molecule ligands, such as metabolites or drugs.
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The genus Manta is part of the eagle ray family Myliobatidae, where it is grouped in the subfamily Mobulinae along with the smaller Mobula devil rays. Manta rays are members of the order Myliobatiformes which consists of stingrays and their relatives. Mantas are known as "devilfish" because of their horn-shaped cephalic fins, which are imagined to give them an "evil" appearance. The name "manta" is Portuguese and Spanish for mantle (cloak or blanket), a type of blanket-shaped trap traditionally used to catch rays. Only a few public aquariums are large enough to house them. Areas where mantas congregate are popular with tourists. They are protected in international waters by the Convention on Migratory Species of Wild Animals, but are more vulnerable closer to shore. Their slow reproductive rate exacerbates these threats. Anthropogenic threats include pollution, entanglement in fishing nets, and direct harvesting of their gill rakers for use in Chinese medicine. Like whales, they breach for unknown reasons.īoth species are listed as vulnerable by the International Union for Conservation of Nature. Mantas may visit cleaning stations for the removal of parasites. Gestation lasts over a year and mantas give birth to live pups. However, research suggests that the majority of their diet (73%) actually comes from mesopelagic sources. They are filter feeders and eat large quantities of zooplankton, which they gather with their open mouths as they swim. alfredi tends to be resident and coastal. birostris migrates across open oceans, singly or in groups, while M. Mantas are found in warm temperate, subtropical and tropical waters. They have the largest brains and brain to body ratio of all fish, and can pass the mirror test. They are classified among the Myliobatiformes ( stingrays and relatives) and are placed in the family Myliobatidae (eagle rays). Both have triangular pectoral fins, horn-shaped cephalic fins and large, forward-facing mouths. birostris, reaches 7 m (23 ft) in width, while the smaller, M. Manta rays are large rays belonging to the genus Mobula (formerly its own genus Manta). With scaling a business, the need to budget the expenses is best dealt with by using dedicated budgeting apps to efficiently track income and expenses. This is why you need the best spending tracker apps to help you out. While it is simpler to track your expenses in ledgers or bank accounts, it can get increasingly overwhelming as the cash flow increases. If your business is in its nascent stage, chances are you must be hustling day in and out to procure funding, planning meetings, or acquiring software tools. You can also include a receipt number for easy tracking.Running a business of your own is easily one of the most rewarding and exciting jobs. Also, make sure it includes key information such as who is issuing the receipt, the date of the transaction, items sold, amount paid and by whom, and the customer’s signature. When choosing a receipt design, consider customization options so it’s unique to your business and harder for someone to replicate with a fraudulent receipt. They can also help reduce employee fraud and theft, and can be used to settle disputes between sellers and customers. Whether digital or paper, receipts help sellers keep track of transactions, providing a detailed record of items sold. Paper receipts can also be helpful when returning an item, especially if the item was a gift and requires a gift receipt. You’ll have to remember to check a digital receipt later, which requires sorting through email messages to find and save the receipt. When customers get a paper receipt at the time of a transaction, they can check to make sure the amounts are accurate. Having hardcopies of receipts can be important when filing taxes or being audited. But there are benefits to printed receipts as well. Many businesses offer the option of receiving a digital (versus paper) receipt, which is great for convenience and customer satisfaction. Managing Work Collections of actionable tips, guides, and templates to help improve the way you work.Solution Center Move faster with templates, integrations, and more.Events Explore upcoming events and webinars.Content Center Get actionable news, articles, reports, and release notes.Partners Find a partner or join our award-winning program.Professional Services Get expert help to deliver end-to-end business solutions.Technical Support Get expert coaching, deep technical support and guidance.Help Center Get answers to common questions or open up a support case.Smartsheet University Access eLearning, Instructor-led training, and certification. 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But its Pro version is even better, offering various forms of customisation such as different themes, saving draft messages, and scheduling when messages should be sent out. MightyText is simple and easy to use on its own, going beyond the basic SMS text-and-send function. This is ideal for users using both platforms, as the transition is smoother when they toggle between Whatsapp Web and MightyText.Īnd if texting from the main MightyText app is not enough, its Gmail plugin is the cherry on top of the cake - it makes sending short messages all the more convenient: Image Credit: Slant Why You Should Go Pro Strangely enough, MightyText also has a image edit option that allows users to sync photos and videos onto the app, and then apply filters, corrections, text, and even stickers onto the image.Īnother perk is that Whatsapp Web and MightyText (in its Classic view) have almost the same message layout: a list of contacts on the left with a preview of the last sent message, and selected recipients expanded on the right. This lets you open and address multiple chat windows, with the option to delete, favourite or forward each and every text within each conversation. Image Credit: MightyTextĪnother cool feature of MightyText is the option to change to Power view. You can call, text, and even check the battery life of your phone at the corner of your 13-inch screen, even if you decide to leave your phone at home. It transforms your laptop or tablet into a mobile phone. Now this is where MightyText proves its worth. Image Credit: NDTV Gadgets What’s Really Good About MightyText All users need to do is point their phone camera at the QR code on their PC, and they can begin messaging on their laptop instantaneously. Whatsapp, in comparison, really got their web synchronisation down pat. You also have to sign in with your Gmail account, and while this entire process takes less than a minute, we would have appreciated a shorter way to get things done. To start your MightyText experience, you have to first install a few extensions for pop-up notifications on your laptop or tablet. One other gripe is that there doesn’t seem to be a shortcut for anything on MightyText. This is where WhatsApp comes in - it is one of the most convenient ways to send and receive videos and photos, and few would see the need to change the status quo by switching over to MightyText. We often send texts without a second thought these days, what with the various unlimited SMS plans on the market. Sending images or gifs in the form of MMS-es, though, is a different story: they are chargeable, and cost quite a bit under some mobile phone plans. There has been some comparison between MightyText and WhatsApp Web, with some saying that WhatsApp Web is superior. This makes it really useful for those without a data plan, or who have exceeded their data limit. Messages sent will be received as SMS-es and MMS-es, though while they sync from Apple to Android, it doesn’t work the other way around. 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Synopsis Macide (Neslihan Atagul) is a young and beautiful girl who has studied psychology and has been working at a private company. According to their deal, Emin will start a new life in Istanbul as a geography teacher at high school and he will act as a husband of a police officer Songul.ĭetails Original Title: Gecenin Ucunda English Title: Poison Ivy Also Known As: Genre: Romance, Drama Episodes: 10+ (each episode is 150 minutes) Broadcast Network: Star TV Broadcast Period: Octo– Present Production Company: TMC Film, Alim Yapim Director: Baris Ercetin Screen Writer: Basar Basaran, Emre Ozdur Filming Locations: Istanbul, Turkey In order to end the underground world and imprison all mafia leaders, the police make a deal with Emin. In exchange for giving information about mafia leaders and evidence to imprison all criminals in the underground world, Emin wants a second chance. He goes to the police department to become a secret witness and disclose all the dirty business going on. After learning that a young girl is killed because of her, Emin decides to leave his dirty past behind. Synopsis Emin (Ertan Saban) is a bully in Ankara. She wants to have a real family and get married to a man whom she loves.ĭetails Original Title: Gelsin Hayat Bildigi Gibi English Title: Another Chance Also Known As: Let Life Come as It Knows Genre: Action, Romance Episodes: 22+ (each episode is 150 minutes) Broadcast Network: Show TV Broadcast Period: J– present Production Company: BKM Director: Altan Donmez Screen Writer: Gani Mujde Filming Locations: Istanbul, Turkey She knows that she cannot become a mother to any man’s child. Even though she does not have any plans to get married soon, she needs to admit that she should start a family if she does not want to lose the opportunity of having a child. The life of Sibel turns upside down when she finds out that she has only three months to have a baby. She devotes herself completely to business and sacrifices her private life for the sake of her career. She is confident, ambitious, and hardworking. She is a successful businesswoman who runs a family business. Synopsis Sibel (Melisa Asli Pamuk) is a beautiful young woman who comes from a wealthy family. Therefore, he periodically changes his identity.ĭetails Original Title: EGO – Erkege Guven Olmaz English Title: EGO – No Trust in the Man Also Known As: Temptation Genre: Romance, Drama Episodes: 13 (each episode is 140-150 minutes) Broadcast Network: Fox Broadcast Period: 5 February 2023 – Production Company: Pastel Film Director: Doga Can Anafarta (1-3), Senol Sonmez (4-13) Screen Writer: Gulsev Karagoz, Zafer Ozer Cetinel, Gorkem Tuzun, Okan Basar Bahar, Ahmet Orcun Oksar, Erkan Birgoren, Elif Tuna Kiygi Filming Locations: Istanbul, Antalya After then, Ali Tahir understands that his secret puts not only his life but also his loved ones’ lives in danger. For this reason, he loses his family and children. His close friend realizes his secret and attempts to abduct him for study. This miracle brings lots of hardships to Ali Tahir’s life. After this miracle, he stays physically 28 years old. Ali Tahir in fact dies on the battlefield but comes back to life with a miracle. He stops aging after being brought back to life from death when he is shot in the battle. Synopsis Ali Tahir (Birkan Sokullu) was born in Thessaloniki in 1893. Details Original Title: Yuz Yillik Mucize English Title: A Hundred Years of Miracle Also Known As: Genre: Romance, Drama Episodes: 13 (each episode is 130-140 minutes) Broadcast Network: Star TV Broadcast Period: Ma– JProduction Company: OGM Pictures Director: Hilal Saral Screen Writer: Nuran Evren Sit Filming Locations: Mugla, Istanbul |
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